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2005). These effects weren't surprising if we take into consideration that PEA is often a poorly water?soluble substance, which can Restrict its oral absorption and bioavailability, Nonetheless they might also propose a short?lived action of PEA, in agreement with The reality that this compound is degraded by two various hydrolases, that is, NAAA a

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PEA guards towards bacterial an infection through innate immune modulation involving MCs, macrophages and microglia. Prophylactic PEA in a dose of 0.1 mg/kg physique fat prolonged survival level and minimized neuro-inflammation in an aged murine bacterial meningitis design, within the absence of antibiotics [42].The exogenous administration of PEA